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Indeed, neuronal progenitors in the Ptbp2-null brain exhibited an aberrant polarity and were associated with regions of premature neurogenesis and reduced progenitor pools. The bone marrow niche is home to a variety of cell types that promote or inhibit the maintenance of HSCs and haematopoietic progenitors. The total number Y -axis of BC2 clusters centered in each nt window relative to alternative and flanking constitutive splice sites is shown for exons that exhibit increased skipping top panel and splicing bottom panel in Ptbp2 knockout compared with wild-type brains. HSCs are defined by their ability to self-renew and to give rise to all the kinds of blood cells in the body. An emerging concept is that, in adult mammals, there may be a population of "universal" stem cells. A second population, called bone marrow stromal stem cells also called mesenchymal stem cells , or skeletal stem cells by some , were discovered a few years later.
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